Jane S. (DeTeso) MacIsaac – of Winchester, Aug. 23, 2010. Beloved wife of the late John F.A. MacIsaac. Loving mother of Karen Murray of VT and the late Jack MacIsaac. Dear sister of Antoinette Tranfaglia, Marie Lizotte and Elizabeth Paonessa, all of Winchester, and the late Anthony, Catherine, Josephine and Rose DeTeso. Devoted grandmother of Dan and John MacIsaac and Trish, Richard, Jessica and Kristin Murray. Funeral Service will be held from the Costello Funeral Home 177 Washington St., Winchester, on Thurs., Aug. 26 @ 10:30 AM followed by a Mass of Christian Burial in St. Mary’s Church 155 Washington St., Winchester at 11AM. Relatives and friends respectfully invited. Interment to follow in Wildwood Cemetery. Visiting Hours will be held on Thurs. from 9-10:30 AM. In lieu of flowers, donations in her memory may be made to the American Cancer Society, 30 Speen St. Framingham, MA 01701.